John M. Lachin, Sc.D. Professor of Biostatistics and Epidemiology, and of Statistics Former Director, the Biostatistics Center The George Washington University 6110 Executive Blvd. Rockville MD 20852 Voice: (301)-816-8081 Fax: (301)-881-3742

r. Lachin is Professor of Biostatistics and Epidemiology, and of Statistics (with tenure). He served as Director of the Biostatistics Center from 1988 through 2000 and is now Co-director.

r. Lachin was born and raised in New Orleans, Louisiana; received his B.S. in experimental psychology from Tulane University in 1965 and his Sc.D. in biostatistics from the University of Pittsburgh in 1972. Dr. Lachin joined the Biostatistics Center as Assistant Research Professor in 1973 and was promoted to Associate Research Professor in 1977 and Research Professor in 1982. Dr. Lachin served as Assistant Director of the Biostatistics Center from 1980-1985, and as Co-Director from 1985-1988.

r. Lachin is currently the Principal Investigator of the coordinating center for the NIH-funded Type 1 Diabetes TrialNet, the study of the Epidemiology of Diabetes Interventions and Complications (EDIC), and the Co- Investigator for the Diabetes Prevention Program (DPP). Previously, he directed the biostatistical coordinating centers for the NIH-funded Diabetes Control and Complications Trial (DCCT) (1981-1998), the Lupus Nephritis Collaborative Study (1981-1988), and the National Cooperative Gallstone Study (1980-1984), among others. The Diabetes Control and Complications Trial Research Group was awarded the Charles H. Best Medal in 1994 by the American Diabetes Association for "Distinguished Service in the Cause of Diabetes."

r. Lachin lead the development of the Graduate Program in Biostatistics and Epidemiology; and served as Director of the Program and as Program Director for Biostatistics from its inception in 1995 until July, 2004. The program is jointly administered by the Department of Statistics of the Columbian School of Arts and Sciences and the Department of Epidemiology and Biostatistics of the School of Public Health and Health Services.

r. Lachin has been elected a Fellow of the American Statistical Association and the Royal Statistical Society, and a member of the International Statistical Institute. He has held offices in various societies and as President of the Society for Clinical Trials for 2002-3.

r. Lachin is the co-author of the graduate reference text, with W. Rosenberger, Randomization in Clinical Trials: Theory and Practice, John Wiley and Sons, 2002 that received the American Association of Publishers award for "The Professional And Scholarly Title Of 2002 In Mathematics And Statistics." He is also the author of the graduate reference text Biostatistical Methods: The Assessment of Relative Risks, John Wiley and Sons, 2000; and a co-editor of the book The Randomized Clinical Trial and Therapeutic Decisions, Marcel-Dekker, 1982.

r. Lachin is a named author of over 85 individual papers, 55 of which concern statistical and research methodology; and either an author or contributor to 105 group-authored medical research papers. His recent named-author publications include papers on the intent-to-treat principle in clinical trials, sample size evaluation, group sequential methods, analysis of repeated measures and survival analysis. His recent group-authored papers include demonstration that a prior period of intensive therapy in the DCCT to maintain near-mormal glycemia in type 1 diabetes reduces the long term development of atherosclerosis (NEJM, 2002) and progression of diabetic kidney disease (JAMA, 2003) during EDIC; and the principal results of the DPP showing that a lifestyle intervention or use of the drug Metformin reduce the risk of developing type 2 diabetes (NEJM, 2002).

Curriculum Vitae

Biostatistical Methods: The Assessment of Relative Risks

Course Materials.

Material available for download.